The Clinical Trials Activity Initiative aims to improve the evidence base supporting clinical care; help patients access trials relevant to their health circumstances; and enable researchers to bring international trials to Australian patients.

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• promote Australian involvement in international collaborative investigator-initiated clinical trials research through the establishment and co-ordination of clinical trial site/s in Australia.
• provide high-quality evidence of the effectiveness of novel health treatments, drugs or devices in ‘usual care’ settings, which will support a decision on whether to deliver the intervention in an Australian setting.

The intended outcome of the research is toimprove the health and wellbeing of Australians by investing in new clinical trials that support increased access to high-quality, evidence-based and effective health care.

Applicants to this grant opportunity must propose a clinical trial in Australia in collaboration with international counterparts. The clinical trial should not have commenced recruitment at the Australian trial site/s.

Please note the 2026 MRFF International Clinical Trial Collaborations grant opportunity will be open for one round only.

This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health, Disability and Ageing.

Applications will only be accepted from NHMRC approved Eligible Organisations. A list of NHMRC approved MRFF Eligible Organisations is available from the GrantConnect Grant Opportunity Documents and from the MRFF Eligible Organisations Institutions list on the NHMRC website.

Applications must satisfy all the requirements set out in the Medical Research Future Fund (MRFF) Clinical Trials Activity Initiative - 2025 International Clinical Trial Collaborations Grant Guidelines.

• Phone: 1800 500 983
• Email: help@nhmrc.gov.au